Guaranteed growth of your money every year. This will be interest-rate-driven based on the economy, but your account will move forward every year regardless of what the market does. This is compound tax-free growth and not the “average rate of return” you get with mutual funds. To be fair, in our current low-interest-rate environment, the growth rates are only in the 2 percent to 4 percent.
We all need some good news and I will give that to you.
The weather is going to improve by next weekend here in the Northwest. Much warmer and even some sun.
But there is also some bad news....we will have to get through a cool/cloudy period first.
Let's face it. It has been cool and murky this week, a situation that heightened the stress of all the virus news. Below are the temperatures at SeaTac during the past two weeks, with the normal highs and lows plotted. Our daily maximum temperatures have been well below normal the last six days. Like 5-10F below normal. Plus lots of clouds and light rain.
Tomorrow will be similar and then a much stronger system, with real rain, will hit Monday, associated an unusually energetic upper level trough (see upper level map for 5 PM Monday). If this was January, we would be worried about lowland snow with such a pattern.
Fortunately, as the week progresses an upper level ridge of high pressure will build along the West Coast and temperatures will rise. To warm you up, here is the latest forecast for high and low temperatures at SeaTac based on the European Center ensemble forecasting system (running their model many times and taking the average). High temperatures climb roughly 10 degrees between this weekend/Monday/Tuesday and later in the week. You will notice that.
The National Weather Service GEFS ensemble of many forecasts shows a cooling trend for a few days, following by warming (see below). Each forecast is plotted with a line and the black line is the average of all of them. Warming towards 60F by April 4/5.
Southern California will warm into the upper 60s to low 70s....perhaps high enough to slow down the coronavirus there. Also clearing skies and progression into spring will produce higher ultraviolet
radiation values along the southern tier of the U.S.: not good news for the virus, which can be degraded or killed by UV. Below are the forecast UV index for Sunday and Wednesday. Big improvement over the western U.S.
This is a good time to plant your spring/cool season veggies if you have a garden. That is my plan this afternoon!
An international team of scientists report in the journal Genome Biology results from a pilot project, co-led by Robert Waterhouse, Group Leader at the SIB Swiss Institute of Bioinformatics and University of Lausanne, to kick-start the global sequencing initiative of thousands of arthropods. Comparative analyses across 76 species spanning 500 million years of evolution reveal dynamic genomic changes that point to key factors behind their success and open up many new areas of research.
The i5k pilot project sequenced, assembled, and annotated the genomes of 28 diverse arthropod species, substantially increasing the current species sampling to explore arthropod genomic diversity over 500 million years of evolution [Credit: Created by Robert M. WaterhouseReuse licensed under CC BY 4.0Milkweed Bug by Chiaki UedaLong-Horned Beetle by Robert Mitchell]
Friends and foes, arthropods rule the world
Arthropods make up the most species-rich and diverse group of animals on Earth, with numerous adaptations over 500 million years of evolution that have allowed them to exploit all major ecosystems. They play vital roles in the healthy ecology of our planet as well as being both beneficial and detrimental to the success of humankind through pollination and biowaste recycling, or destroying crops and spreading disease.
"By sequencing and comparing their genomes we can begin to identify some of the key genetic factors behind their evolutionary success," explains Waterhouse, "but will the impact of human activities in modern times bring an end to their rule, or will their ability to adapt and innovate ensure their survival?"
The i5k pilot project: kick-starting arthropod genome sequencing
The i5k initiative to sequence and annotate the genomes of 5000 species of insects and other arthropods, was launched in a letter to Science in 2011. From the outset, the initiative aimed to support the development of new genomic resources for understanding the molecular biology and evolution of arthropods.
Since then, the i5k has grown into a broad community of scientists using genomics to study insects and other arthropods in many different contexts from fundamental animal biology, to effects on ecology and the environment, and impacts on human health and agriculture.
To kick-start the i5k, a pilot project was launched at the Baylor College of Medicine led by Stephen Richards to sequence, assemble, and annotate the genomes of 28 diverse arthropod species carefully selected from 787 community nominations.
Large-scale multi-species genome comparisons
"The identification and annotation of thousands of genes from the i5k pilot project substantially increases our current genomic sampling of arthropods," says Waterhouse.
The evolutionary innovations of insects and other arthropods are as numerous as they are wondrous, from terrifying fangs
and stingers to exquisitely coloured wings and ingenious feats of engineering. DNA sequencing allows us to chart the
genomic blueprints underlying this incredible diversity that characterises the arthropods and makes them the most
successful group of animals on Earth. An international team of scientists report in the journal Genome Biology results
from a pilot project, co-led by SIB Group Leader Robert Waterhouse at the University of Lausanne, to kick-start the
global sequencing initiative of thousands of arthropods. Comparative analyses across 76 species spanning
500 million years of evolution reveal dynamic genomic changes that point to key factors behind
their success and open up many new areas of research [Credit: Robert Waterhouse]
Combining these with previously sequenced genomes enabled the researchers to perform a large-scale comparative analysis across 76 diverse species including flies, butterflies, moths, beetles, bees, ants, wasps, true bugs, thrips, lice, cockroaches, termites, mayflies, dragonflies, damselflies, bristletails, crustaceans, centipedes, spiders, ticks, mites, and scorpions.
PhD students Gregg Thomas from Indiana University, USA, and Elias Dohmen from the University of Munster, Germany, used the annotated genomes to perform the computational evolutionary analyses of more than one million arthropod genes.
Dynamic gene family evolution - a key to success?
The team's analyses focused on tracing gene evolutionary histories to estimate changes in gene content and gene structure over 500 million years. This enabled identification of families of genes that have substantially increased or decreased in size, or newly emerged or disappeared, or rearranged their protein domains, between and within each of the major arthropod subgroups.
The gene families found to be most dynamically changing encode proteins involved in functions linked to digestion, chemical defence, and the building and remodelling of chitin - a major part of arthropod exoskeletons.
Adaptability of digestive processes and mechanisms to neutralise harmful chemicals undoubtedly served arthropods well as they conquered a wide variety of ecological niches. Perhaps even more importantly, the flexibility that comes with a segmented body plan and a dynamically remodellable exoskeleton allowed them to thrive by physically adapting to new ecosystems.
Innovation through invention and repurposing
Newly evolved gene families also reflect functions known to be important in different arthropod groups, such as visual learning and behaviour, pheromone and odorant detection, neuronal activity, and wing development. These may enhance food location abilities or fine-tune species self-recognition and communication.
In contrast, few changes were identified in the ancestor of insects that undergo complete metamorphosis: the dramatic change from the juvenile form to the fully developed adult (like a caterpillar transforming into a butterfly). This has traditionally been thought of as a major step in the evolution of insects from the original state of developing through gradual nymph stages until finally reaching the adult stage.
"These findings support the idea that this key transition is more likely to have occurred through the rewiring of existing gene networks or building new networks using existing genes, a scenario of new-tricks-for-old-genes" explains Waterhouse.
Genomic insights into arthropod biology and evolution
Several detailed genomic studies of individual i5k species have focused on their fascinating biological traits such as the feeding ecology and developmental biology of the milkweed bug, insecticide resistance, blood feeding, and traumatic sex of the bed bug, horizontal gene transfer from bacteria and fungi and digestion of plant materials by the Asian long-horned beetle, and parasite-host interactions and potential vaccines for the sheep blowfly. The combined analyses reveal dynamically changing and newly emerged gene families that will stimulate new areas of research.
"We can take these hypotheses into the lab and use them to directly study how the genome is translated into visible morphology at a resolution that cannot be achieved with any other animal group," says co-lead author, Ariel Chipman, from the Hebrew University of Jerusalem, Israel.
The new resources substantially advance progress towards building a comprehensive genomic catalogue of life on our planet, and with more than a million described arthropod species and estimates of seven times as many, there clearly remains a great deal to discover!
Next steps in arthropod genomics and beyond
More effective and cost-efficient DNA sequencing technologies mean that new ambitious initiatives are already underway to sequence the genomes of additional arthropods. These include the Global Ant Genome Alliance and the Global Invertebrate Genomics Alliance, as well as the Darwin Tree of Life Project that is targeting all known species of animals in the British Isles, and the global network of communities coordinated by the Earth BioGenome Project (EBP) that aims to sequence all of Earth's eukaryotic biodiversity7.
The EBP's goals also include benefitting human welfare, where the roles of arthropods are clear and the hidden benefits are likely to be substantial, as well as protecting biodiversity and understanding ecosystems, where alarming reports of declining numbers make arthropods a priority.
"The completion of the i5k pilot project therefore represents an important milestone in the progress towards intensifying efforts to develop a comprehensive genomic catalogue of life on our planet", concludes Richards.
When the Earth was born, it was a mess. Meteors and lightning storms likely bombarded the planet's surface where nothing except lifeless chemicals could survive. How life formed in this chemical mayhem is a mystery billions of years old. Now, a new study offers evidence that the first building blocks may have matched their environment, starting out messier than previously thought.
Szostak believes the earliest cells developed on land in ponds or pools, potentially in volcanically active regions. Ultraviolet light, lightning strikes, and volcanic eruptions all could have helped spark the chemical reactions necessary for life formation [Credit: Don Kawahigashi/Unsplash]
Life is built with three major components: RNA and DNA--the genetic code that, like construction managers, program how to run and reproduce cells--and proteins, the workers that carry out their instructions. Most likely, the first cells had all three pieces. Over time, they grew and replicated, competing in Darwin's game to create the diversity of life today: bacteria, fungi, wolves, whales and humans.
But first, RNA, DNA or proteins had to form without their partners. One common theory, known as the "RNA World" hypothesis, proposes that because RNA, unlike DNA, can self-replicate, that molecule may have come first. While recent studies discovered how the molecule's nucleotides--the A, C, G and U that form its backbone--could have formed from chemicals available on early Earth, some scientists believe the process may not have been such a straightforward path.
"Years ago, the naive idea that pools of pure concentrated ribonucleotides might be present on the primitive Earth was mocked by Leslie Orgel as 'the Molecular Biologist's Dream,'" said Jack Szostak, a Nobel Prize Laureate, professor of chemistry and chemical biology and genetics at Harvard University, and an investigator at the Howard Hughes Medical Institute. "But how relatively modern homogeneous RNA could emerge from a heterogeneous mixture of different starting materials was unknown."
In a paper published in the Journal of the American Chemical Society, Szostak and colleagues present a new model for how RNA could have emerged. Instead of a clean path, he and his team propose a Frankenstein-like beginning, with RNA growing out of a mixture of nucleotides with similar chemical structures: arabino- deoxy- and ribonucleotides (ANA, DNA, and RNA).
In the Earth's chemical melting pot, it's unlikely that a perfect version of RNA formed automatically. It's far more likely that many versions of nucleotides merged to form patchwork molecules with bits of both modern RNA and DNA, as well as largely defunct genetic molecules, such as ANA. These chimeras, like the monstrous hybrid lion, eagle and serpent creatures of Greek mythology, may have been the first steps toward today's RNA and DNA.
"Modern biology relies on relatively homogeneous building blocks to encode genetic information," said Seohyun Kim, a postdoctoral researcher in chemistry and first author on the paper. So, if Szostak and Kim are right and Frankenstein molecules came first, why did they evolve to homogeneous RNA?
Kim put them to the test: He pitted potential primordial hybrids against modern RNA, manually copying the chimeras to imitate the process of RNA replication. Pure RNA, he found, is just better--more efficient, more precise, and faster--than its heterogeneous counterparts. In another surprising discovery, Kim found that the chimeric oligonucleotides--like ANA and DNA--could have helped RNA evolve the ability to copy itself. "Intriguingly," he said, "some of these variant ribonucleotides have been shown to be compatible with or even beneficial for the copying of RNA templates."
If the more efficient early version of RNA reproduced faster than its hybrid counterparts then, over time, it would out-populate its competitors. That's what the Szostak team theorizes happened in the primordial soup: Hybrids grew into modern RNA and DNA, which then outpaced their ancestors and, eventually, took over.
"No primordial pool of pure building blocks was needed," Szostak said. "The intrinsic chemistry of RNA copying chemistry would result, over time, in the synthesis of increasingly homogeneous bits of RNA. The reason for this, as Seohyun has so clearly shown, is that when different kinds of nucleotides compete for the copying of a template strand, it is the RNA nucleotides that always win, and it is RNA that gets synthesized, not any of the related kinds of nucleic acids."
So far, the team has tested only a fraction of the possible variant nucleotides available on early Earth. So, like those first bits of messy RNA, their work has only just begun.
Certain types of domesticated wheat have complicated origins, with genetic contributions from wild and cultivated wheat populations on opposite sides of the Fertile Crescent. Terence Brown and colleagues at the University of Manchester report these findings in a new paper published in the open-access journal PLOS ONE.
Credit: WikiCommons
A wild form of wheat called emmer wheat was one of the first plant species that humans domesticated. Emmer is not grown widely today, but gave rise to the durum wheat used for pasta and hybridized with another grass to make bread wheat, so its domestication was an important step in the transition from hunting and gathering to agriculture.
While the archaeological record suggests that cultivation began in the southern Levant region bordering the eastern edge of the Mediterranean Sea around 9,500 years ago, genetic studies point to an origin in the northern region of the Fertile Crescent, in what is now Turkey. To clarify emmer's origins, researchers screened 189 types of wild and domesticated wheats and used the more that 1 million genetic variations that they identified to piece together the genetic relationships between different kinds of wheat.
Based on the analysis, the researchers propose that an emmer crop, which humans cultivated but had not yet domesticated, spread from the southern Levant to southeast Turkey, where it mixed with a wild emmer population and ultimately yielded the first domesticated variety. The results of this hybridization can be detected in wild emmer plants in Turkey today.
The complex evolutionary relationships between wild emmer and cultivated wheat varieties uncovered by the analysis are similar to the interbreeding that occurred between wild and cultivated populations of other grain crops, such as barley and rice.
The authors add: "We used next-generation DNA sequencing technologies to detect hundreds of thousands of variants in the genomes of wild and cultivated emmer wheat, giving us an unprecedented insight into the complexity of its domestication process. The patterns we observed do not fit well with a simplistic model of fast and localized domestication event but suggest instead a long process of cultivation of wild wheat by hunter-gatherer communities connected throughout the Fertile Crescent, prior to the emergence of a fully domesticated wheat form."
Munere veritus fierent cu sed, congue altera mea te, ex clita eripuit evertitur duo. Legendos tractatos honestatis ad mel. Legendos tractatos honestatis ad mel.
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